Gannon Lab Publications


Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007

Wiebe, PO, Korminsh, JD, Roper, VT, Fujitani, Y, Alston, NI, Zaret, KS, Wright, CV, Stein, RW, Gannon, M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 Expression. Mol Cell Biol, 27(11), 4093-204, 2007

Boyer, DF, Fujitani, Y, Gannon, M, Powers, AC, Stein, RW, Wright, CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol, 298(2), 616-31, 2006

Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11), 2974-85, 2006

Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006

Tweedie, E, Artner, I, Crawford, L, Poffenberger, G, Thorens, B, Stein, R, Powers, AC, Gannon, M.  Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta cells.  Diabetes, 55(12), 3264-70, 2006

Zhang, H, Ackermann, AM, Gusarova, GA, Lowe, D, Feng, X, Kopsombut, UG, Costa, RH, Gannon, M. The Foxm1 Transcription Factor is Required to Maintain Pancreatic Beta Cell Mass. Mol Endocrinol, 20(8), 1853-66, 2006

Fujitani, Y., S. Fujitani, D. Boyer, M. Gannon, Y. Kawaguchi, M.K. Ray, M. Shiota, R.W. Stein, M.A. Magnuson, and C.V.E. Wright. Targeted deletion of cis-regulatory region for pdx1 reveals dosage responses of foregut differentiation, pancreas organogenesis, and function. Genes and Development, 20(2), 253-66, 2006.

Zhang, H, Fujitani, Y, Wright, CV, Gannon, M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis, 42(3), 210-7, 2005

Brissova, Marcela, Fowler, Michael, Wiebe, Peter, Shostak, Alena, Shiota, Masakazu, Radhika, Aramandla, Lin, P Charles, Gannon, Maureen, Powers, Alvin C. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes, 53(5), 1318-25, 2004

Frigeri, Claudia, Martin, Cyrus C, Svitek, Christina A, Oeser, James K, Hutton, John C, Gannon, Maureen, O''Brien, Richard M. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Diabetes, 53(7), 1754-64, 2004.

Brissova, Marcela, Shiota, Masakazu, Nicholson, Wendell E, Gannon, Maureen, Knobel, Susan M, Piston, David W, Wright, Christopher V E, Powers, Alvin C. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem, 277(13), 11225-32, 2002

Kawaguchi, Yoshiya, Cooper, Bonnie, Gannon, Maureen, Ray, Michael, MacDonald, Raymond J, Wright, Christopher V E. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet, 32(1), 128-34, 2002

Samaras, Susan E, Cissell, Michelle A, Gerrish, Kevin, Wright, Christopher V E, Gannon, Maureen, Stein, Roland. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol, 22(13), 4702-13, 2002

Zhang, Peichuan, McGrath, Barbara, Li, Sheng'ai, Frank, Ami, Zambito, Frank, Reinert, Jamie, Gannon, Maureen, Ma, Kun, McNaughton, Kelly, Cavener, Douglas R. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol, 22(11), 3864-74, 2002

Dutta, S, Gannon, M, Peers, B, Wright, C, Bonner-Weir, S, Montminy, M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A, 98(3), 1065-70, 2001

Gannon, M, Gamer, L W, Wright, C V. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol, 238(1), 185-201, 2001

Gannon, M, Gilday, D, Rifkind, A B. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol Appl Pharmacol, 164(1), 24-37, 2000

Gannon, M, Herrera, P L, Wright, C V. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis, 26(2), 143-4, 2000

Gannon, M, Ray, M K, Van Zee, K, Rausa, F, Costa, R H, Wright, C V. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development, 127(13), 2883-95, 2000

Gannon, M, Shiota, C, Postic, C, Wright, C V, Magnuson, M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis, 26(2), 139-42, 2000

Gerrish, K, Gannon, M, Shih, D, Henderson, E, Stoffel, M, Wright, C V, Stein, R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J Biol Chem, 275(5), 3485-92, 2000

Song, S Y, Gannon, M, Washington, M K, Scoggins, C R, Meszoely, I M, Goldenring, J R, Marino, C R, Sandgren, E P, Coffey, R J, Wright, C V, Leach, S D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999

Wu, K L, Gannon, M, Peshavaria, M, Offield, M F, Henderson, E, Ray, M, Marks, A, Gamer, L W, Wright, C V, Stein, R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol, 17(10), 6002-13, 1997

Gilday, D, Gannon, M, Yutzey, K, Bader, D, Rifkind, A B. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem, 271(51), 33054-9, 1996

Gannon, M, Bader, D. Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Development, 121(8), 2439-50, 1995

Yutzey, K, Gannon, M, Bader, D. Diversification of cardiomyogenic cell lineages in vitro. Dev Biol, 170(2), 531-41, 1995

Nakai, K, Ward, A M, Gannon, M, Rifkind, A B. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase. J Biol Chem, 267(27), 19503-12, 1992

Wang, G, Higgins, P J, Gannon, M, Staiano-Coico, L. Transforming growth factor-beta 1 acts cooperatively with sodium n-butyrate to induce differentiation of normal human keratinocytes. Exp Cell Res, 198(1), 27-30, 1992

Rifkind, A B, Gannon, M, Gross, S S. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochem Biophys Res Commun, 172(3), 1180-8, 1990



Gannon, M., K. Gerrish, R. Stein and C.V.E. Wright. (2000). Role of pdx-1 in pancreatic development. Frontiers in Diabetes: Molecular pathogenesis of MODYs. F.M. Matschinsky and M.A. Magnuson, Eds. S. Karger AG. Basel, Switzerland. pp. 166-180.


Gannon, M. and C.V.E. Wright. (1999). Endoderm patterning and organogenesis. Cell Lineage and Fate Determination. Sally Moody, Ed. Academic Press. San Diego, CA. pp. 583-615.

Gannon, M, Bader, D. Avian cardiac progenitors: methods for isolation, culture, and analysis of differentiation. Methods Cell Biol, 52, 117-32, 1997

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