Keith T. Wilson, M.D.

Thomas F. Frist, Sr. Professor of Medicine , Department of Medicine

Director of Research, Division of Gastroenterology, Hepatology & Nutrition

Director, Vanderbilt Center for Mucosal Inflammation and Cancer


Background 

Dr. Wilson is a graduate of the College of Arts and Sciences at Cornell University in Ithaca, NY, where he was in the College Scholar Honors Program. He received his M.D. from Harvard Medical School. He completed residency in Internal Medicine at Case Western Reserve University Hospitals, followed by Fellowship in Gastroenterology at University of Chicago Medical Center, where he was an NIH T32 trainee and recipient of a Research Fellowship Award from the Crohn’s & Colitis Foundation of America (CCFA). He was then recruited to University of Maryland School of Medicine as an Assistant Professor, and was promoted to Associate Professor with tenure. He was able to secure funding from the CCFA, followed by NIH K08 and R01 funding and a VA Merit Review. He served as the Gastroenterology Section Chief at the Baltimore VA Medical Center from 2002-2005. He moved to Vanderbilt University Medical Center in 2005 as Professor of Medicine, where he was recruited to build a mucosal immunology research program.

Keith T. Wilson, M.D. holds the Thomas F. Frist Sr. Chair in Medicine, and is Professor of Medicine, Cancer Biology, and Pathology, Microbiology and Immunology at Vanderbilt University School of Medicine. He is a physician-scientist in the area of Gastrointestinal Research. He is a Staff Physician at the VA Tennessee Valley Healthcare System in Nashville, where he does endoscopy and GI consults. He is the Director of Research in the Division of Gastroenterology, Hepatology and Nutrition and formerly was the Director of the GI Fellowship Program from 2005 to 2015.

His research is focused on GI inflammation and carcinogenesis, with studies  investigating both Helicobacter pylori-associated immune dysregulation and gastric cancer development and Inflammatory Bowel Disease. The work in his laboratory related to polyamines in gastric carcinogenesis has led to a clinical trial in Latin America in which an inhibitor of polyamine synthesis, difluoromethylornithine (DFMO, eflornithine) is being used in human subjects with gastric precancerous lesions. Dr. Wilson is the Founding Director of the Vanderbilt CMIC. He holds multiple grants from NIH and the Department of Veterans Affairs. He is the Associate Director of the Vanderbilt Digestive Disease Research Center, funded by an NIH P30 grant, where he directs the Pilot and Feasibility Grant Program. He is also the Director of the Digestive Disease Research component of the NIH T35-funded Summer Research Training Program and he has mentored over 100 trainees. He has presented the work from his laboratory at numerous international meetings, including the Keynote Lecture at the 2016 American Society for Oncology GI Cancer Symposium. He has been elected as the 2017 Vice Chair and 2019 Chair of the Gordon Research Conference on Polyamines. 

Education

M.D., Medicine, Harvard Medical School, Boston, Massachusetts
B.A., Biology/Anthropolopy, Cornell University, Ithaca, New York

Research Description 

My laboratory is focused on gastrointestinal mucosal inflammation and carcinogenesis. We study the host immune response to the gastric pathogen Helicobacter pylori that causes peptic ulcer disease and gastric cancer. This includes the innate immune response in macrophages and the identification of ways that this response is ineffective. We have also elucidated mechanisms whereby epithelial responses are inappropriate, leading to risk for cancer development. We study novel mechanisms for inflammation and cellular/DNA damage, which leads to increased cancer risk.

We have reported that H. pylori induces the enzyme spermine oxidase (SMOX), originally known as polyamine oxidase 1, which utilizes the polyamine spermine as substrate. Generation of H2O2 by SMOX results in mitochondrial membrane depolarization, cytochrome c release, and apoptosis. Spermine itself contributes to the inadequacy of the host response, by blocking translation of inducible nitric oxide (NO) synthase (iNOS) and hence NO production that is needed for the killing of H. pylori. Upregulation of SMOX causes oxidative stress in gastric epithelial cells that leads to both apoptosis and DNA damage. Induction of ornithine decarboxylase (ODC) that generates polyamines also leads to apoptosis of macrophages, contributing to loss of host innate immunity to H. pylori. We have shown that induction of the transcription factor c-Myc by H. pylori enhances ODC transcription and has a causal role in macrophage apoptosis. We have also implicated formation of a specific AP-1 complex in the activation of c-Myc.

We are utilizing clinical material from a large cohort of human subjects from Colombia, South America where H. pylori infection prevalence is very high, but gastric cancer risk is 25-fold higher in the Andean mountains when compared to the coastal region. We have found that SMOX-dependent oxidative stress is increased in gastric epithelial cells in vivo in the subjects at high risk for gastric cancer and that H. pylori clinical strains from these subjects induce more SMOX and oxidative DNA damage both in vitro and in vivo in a gerbil model. Furthermore, inhibition of ODC or SMOX reduces gastric cancer in the gerbil model. Studies are ongoing to pursue the mechanisms involved in the differential induction of SMOX and DNA damage.

We are also pursuing studies on immune dysregulation in inflammatory bowel disease. This includes work on arginine availability/transport, polyamines, and nitric oxide. We have reported that levels of the amino acid L-arginine are increased in the serum of humans with ulcerative colitis. Because L-arginine is important in regulation of epithelial integrity and immune function a defect in the utilization of L-arginine could contribute to the disease pathogenesis. Consistent with this, we have shown that treatment with L-arginine improves colitis in mouse models and that mice lacking an inducible L-arginine transporter have increased disease activity.

Our funded studies are focused on: 
1) Mechanisms of H. pylori induced DNA damage and immune dysregulation, with an emphasis on the effects of polyamines and their oxidation (PI, R01 grant)
2) The role oxidative and nitrosative stress in the development of gastric cancer in Colombia, and the importance of H. pylori strains from regions of low and high gastric cancer risk in modulation of host responses (PI, P01 grant)
3) Importance of arginine metabolism in the immune response to H. pylori (PI, VA Merit Review Grant)
4) Role of EGFR signaling and polyamines in epithelial dysfunction in H. pylori infection and carcinogenesis (PI, project on P01)
5) Inhibition of polyamine synthesis with difluoromethylornithine in human subjects in Colombia and Honduras with precancerous gastric lesions (PI, R01 grant).
6) Arginine and other amino acids as immunomodulatory agents and potential therapies in colitis and colitis-associated cancer (PI, R01 grant)
7) Clinical study on amino acids in ulcerative colitis (PI- R01 supplement; funding completed, analysis ongoing)

Research Keywords:

Mucosal immunology, mechanisms of inflammation, oxidative stress and gastrointestinal carcinogenesis, host-pathogen interactions, inflammatory bowel disease, Helicobacter pylori infection

Publications 

Gobert AP, Latour YL, Asim M, Finley JL, Verriere TG, Barry DP, Milne GL, Luis PB, Schneider C, Rivera ES, Lindsey-Rose K, Schey KL, Delgado AG, Sierra JC, Piazuelo MB, Wilson KT. Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway. MBio. 2019 Oct 29;10(5). pii: e02174-19. doi: 10.1128/mBio.02174-19. PMID: 31662455​

 

Bajaj JS, Sharma A, Dudeja PK, Iqbal Z, Singh AB, Wilson KT, Tache Y, Pisegna J, Greenwood-Van Meerveld B, Sartor RB, Hecht G, Zhou H, Hylemon P, Im HJ, Jacobs J, Skupsky J, Sun J, Benhammou J, Ince ME, Voburn LA, Brenner L, Safdar N, Gillevat PM. Targeting Gut Microbiome Interactions in Service-Related Gastrointestinal and Liver Diseases of Veterans. Gastroenterology. 2019 Nov;157(5):1180-1183.e1. doi: 10.1053/j.gastro.2019.07.060. Epub 2019 Aug 9. No abstract available. PMID: 31404532

 

Dominguez RL, Cherry CB, Estevez-Ordonez D, Mera R, Escamilla V, Pawlita M, Waterboer T, Wilson KT, Peek RM, Tavera G, Williams SM, Gulley ML, Emch M, Morgan DR. Geospatial analyses identify regional hot spots of diffuse gastric cancer in rural Central AmericaBMC Cancer. 2019 Jun 6/7/2019; 19(1): 545. PMID: 31174492, PII: 10.1186/s12885-019-5726-x, DOI: 10.1186/s12885-019-5726-x, ISSN: 1471-2407.

Ortiz V, Estevez-Ordonez D, Montalvan-Sanchez E, Urrutia-Argueta S, Israel D, Krishna US, Romero-Gallo J, Wilson KT, Peek RM, Dominguez R, Morgan DR. Helicobacter pylori antimicrobial resistance and antibiotic consumption in the low-resource Central America settingHelicobacter [print-electronic]. 2019 May 5/20/2019; e12595. PMID: 31111610, DOI: 10.1111/hel.12595, ISSN: 1523-5378. 

Latour YL, Gobert AP, Wilson KTThe role of polyamines in the regulation of macrophage polarization and functionAmino Acids [print-electronic]. 2019 Apr 4/23/2019; PMID: 31016375, PII: 10.1007/s00726-019-02719-0, DOI: 10.1007/s00726-019-02719-0, ISSN: 1438-2199. 

Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS. Kaiso is required for MTG16-dependent effects on colitis-associated carcinomaOncogene [print-electronic]. 2019 Mar 3/11/2019; PMID: 30858547, PII: 10.1038/s41388-019-0777-7, DOI: 10.1038/s41388-019-0777-7, ISSN: 1476-5594. 

Scoville EA, Allaman MM, Adams DW, Motley AK, Peyton SC, Ferguson SL, Horst SN, Williams CS, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's DiseaseSci Rep. 2019 Feb 2/27/2019; 9(1): 2882. PMID: 30814550, PMCID: PMC6393448, PII: 10.1038/s41598-019-39232-z, DOI: 10.1038/s41598-019-39232-z, ISSN: 2045-2322. 

Sierra JC, Suarez G, Piazuelo MB, Luis PB, Baker DR, Romero-Gallo J, Barry DP, Schneider C, Morgan DR, Peek RM, Gobert AP, Wilson KTA-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagYProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2019 Feb 2/25/2019; PMID: 30804204, PII: 1814497116, DOI: 10.1073/pnas.1814497116, ISSN: 1091-6490. 

Noto JM, Rose KL, Hachey AJ, Delgado AG, Romero-Gallo J, Wroblewski LE, Schneider BG, Shah SC, Cover TL, Wilson KT, Israel DA, Roa JC, Schey KL, Zavros Y, Piazuelo MB, Peek RM. Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer ProgressionMol. Cell Proteomics [print-electronic]. 2019 Feb; 18(2): 352-71. PMID: 30455363, PMCID: PMC6356085, PII: RA118.001181, DOI: 10.1074/mcp.RA118.001181, ISSN: 1535-9484. 

Suarez G, Romero-Gallo J, Piazuelo MB, Sierra JC, Delgado AG, Washington MK, Shah SC, Wilson KT, Peek RM. Nod1 imprints inflammatory and carcinogenic responses toward the gastric pathogen Helicobacter pyloriCancer Res [print-electronic]. 2019 Jan 1/29/2019; PMID: 30696658, PII: 0008-5472.CAN-18-2651, DOI: 10.1158/0008-5472.CAN-18-2651, ISSN: 1538-7445. 

Singh K, Gobert AP, Coburn LA, Barry DP, Allaman M, Asim M, Luis PB, Schneider C, Milne GL, Boone HH, Shilts MH, Washington MK, Das SR, Piazuelo MB, Wilson KTDietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic MicrobiomeFront Cell Infect Microbiol. 2019; 9: 66. PMID: 30972302, PMCID: PMC6443829, DOI: 10.3389/fcimb.2019.00066, ISSN: 2235-2988. 

Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KTLoss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesisOncogene [print-electronic]. 2018 Sep 9/10/2018; PMID: 30202097, PII: 10.1038/s41388-018-0492-9, DOI: 10.1038/s41388-018-0492-9, ISSN: 1476-5594. 

Blosse A, Lehours P, Wilson KT, Gobert AP. Helicobacter: Inflammation, immunology, and vaccinesHelicobacter. 2018 Sep; 23 Suppl 1: e12517. PMID: 30277626, DOI: 10.1111/hel.12517, ISSN: 1523-5378. 

Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS. BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeabilityMucosal Immunol [print-electronic]. 2018 Jun 6/15/2018; PMID: 29907869, PII: 10.1038/s41385-018-0043-2, DOI: 10.1038/s41385-018-0043-2, ISSN: 1935-3456. 

Shen X, Liu L, Peek RM, Acra SA, Moore DJ, Wilson KT, He F, Polk DB, Yan F. Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomesMucosal Immunol [print-electronic]. 2018 Jun 6/6/2018; PMID: 29875401, PII: 10.1038/s41385-018-0034-3, DOI: 10.1038/s41385-018-0034-3, ISSN: 1935-3456. 

Singh K, Coburn LA, Asim M, Barry DP, Allaman MM, Shi C, Washington MK, Luis PB, Schneider C, Delgado AG, Piazuelo MB, Cleveland JL, Gobert AP, Wilson KTOrnithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune ResponsesCancer Res [print-electronic]. 2018 May 5/31/2018; PMID: 29853605, PII: 0008-5472.CAN-18-0116, DOI: 10.1158/0008-5472.CAN-18-0116, ISSN: 1538-7445. 

Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic ProfilingMetabolomics [print-electronic]. 2018 Jan; 14(1): PMID: 29681789, PMCID: PMC5907923, DOI: 10.1007/s11306-017-1311-y, ISSN: 1573-3882. 

Gobert AP, Al-Greene NT, Singh K, Coburn LA, Sierra JC, Verriere TG, Luis PB, Schneider C, Asim M, Allaman MM, Barry DP, Cleveland JL, Destefano Shields CE, Casero RA, Washington MK, Piazuelo MB, Wilson KTDistinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or InfectionFront Immunol. 2018; 9: 1242. PMID: 29922289, PMCID: PMC5996034, DOI: 10.3389/fimmu.2018.01242, ISSN: 1664-3224.

Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated CancerCell Mol Gastroenterol Hepatol. 2018; 6(3): 257-76. PMID: 30109253, PMCID: PMC6083016, PII: S2352-345X(18)30082-1, DOI: 10.1016/j.jcmgh.2018.05.006, ISSN: 2352-345X. 

Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated CancerCell Mol Gastroenterol Hepatol. 2018; 6(3): 257-76. PMID: 30109253, PMCID: PMC6083016, PII: S2352-345X(18)30082-1, DOI: 10.1016/j.jcmgh.2018.05.006, ISSN: 2352-345X. 

Noto JM, Chopra A, Loh JT, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett AC, Wilson KT, Cover TL, Mallal S, Israel DA, Peek RM. Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironmentsGut [print-electronic]. 2017 Sep 9/18/2017; PMID: 28924022, PII: gutjnl-2017-313863, DOI: 10.1136/gutjnl-2017-313863, ISSN: 1468-3288. 

McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. MTG16 is a tumor suppressor in colitis-associated carcinomaJCI Insight [print-electronic]. 2017 Aug 8/17/2017; 2(16): PMID: 28814670, PII: 78210, DOI: 10.1172/jci.insight.78210, ISSN: 2379-3708. 

Mera RM, Bravo LE, Camargo MC, Bravo JC, Delgado AG, Romero-Gallo J, Yepez MC, Realpe JL, Schneider BG, Morgan DR, Peek RM, Correa P, Wilson KT, Piazuelo MB. Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trialGut [print-electronic]. 2017 Jun 6/24/2017; PMID: 28647684, PII: gutjnl-2016-311685, DOI: 10.1136/gutjnl-2016-311685, ISSN: 1468-3288. 

Gobert AP, Wilson KTEffect of CO2 on Peroxynitrite-Mediated Bacteria Killing: Response to Tsikas et al [letter]Trends Microbiol [print-electronic]. 2017 Jun 6/10/2017; PMID: 28610877, PII: S0966-842X(17)30123-3, DOI: 10.1016/j.tim.2017.05.009, ISSN: 1878-4380. 

Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM, Gobert AP, Wilson KTEpidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesisGut [print-electronic]. 2017 May 5/4/2017; PMID: 28473630, PII: gutjnl-2016-312888, DOI: 10.1136/gutjnl-2016-312888, ISSN: 1468-3288. 

Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesisGut [print-electronic]. 2017 May; 66(5): 852-62. PMID: 28389570, PMCID: PMC5385850, PII: gutjnl-2015-310255, DOI: 10.1136/gutjnl-2015-310255, ISSN: 1468-3288. 

Pazos A, Kodaman N, Piazuelo MB, Romero-Gallo J, Sobota RS, Israel DA, Bravo LE, Morgan DR, Wilson KT, Correa P, Peek RM, Williams SM, Schneider BG. Draft Genome Sequences of 13 Colombian Helicobacter pylori Strains Isolated from Pacific Coast and Andean ResidentsGenome Announc. 2017 Apr 4/13/2017; 5(15): PMID: 28408665, PII: 5/15/e00113-17, DOI: 10.1128/genomeA.00113-17. 

Garay J, Piazuelo MB, Lopez-Carrillo L, Leal YA, Majumdar S, Li L, Cruz-Rodriguez N, Serrano-Gomez SJ, Busso CS, Schneider BG, Delgado AG, Bravo LE, Crist AM, Meadows SM, Camargo MC, Wilson KT, Correa P, Zabaleta J. Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studiesOncotarget [print-electronic]. 2017 Apr 4/3/2017; PMID: 28423364, PII: 16792, DOI: 10.18632/oncotarget.16792, ISSN: 1949-2553. 

Hardbower DM, Coburn LA, Asim M, Singh K, Sierra JC, Barry DP, Gobert AP, Piazuelo MB, Washington MK, Wilson KTEGFR-mediated macrophage activation promotes colitis-associated tumorigenesisOncogene [print-electronic]. 2017 Mar 3/6/2017; PMID: 28263971, PII: onc201723, DOI: 10.1038/onc.2017.23, ISSN: 1476-5594. 

Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infectionMucosal Immunol [print-electronic]. 2017 Mar; 10(2): 493-507. PMID: 27435104, PMCID: PMC5250617, PII: mi201660, DOI: 10.1038/mi.2016.60, ISSN: 1935-3456. 

Suarez G, Romero-Gallo J, Sierra JC, Piazuelo MB, Krishna U, Gomez MA, Wilson KT, Peek RM. Genetic manipulation of Helicobacter pylori virulence function by host carcinogenic phenotypesCancer Res [print-electronic]. 2017 Feb 2/16/2017; PMID: 28209611, PII: 0008-5472.CAN-16-2922, DOI: 10.1158/0008-5472.CAN-16-2922, ISSN: 1538-7445. 

Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA. Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-only Crohn's Disease in Treatment-naïve Pediatric PatientsGastroenterology [print-electronic]. 2017 Jan 1/26/2017; PMID: 28132889, PII: S0016-5085(17)30073-2, DOI: 10.1053/j.gastro.2017.01.016, ISSN: 1528-0012. 

Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KTOrnithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modificationsProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Jan 1/17/2017; PMID: 28096401, PII: 1614958114, DOI: 10.1073/pnas.1614958114, ISSN: 1091-6490. 

Gobert AP, Wilson KTHuman and Helicobacter pylori Interactions Determine the Outcome of Gastric DiseasesCurr. Top. Microbiol. Immunol. 2017; 400: 27-52. PMID: 28124148, DOI: 10.1007/978-3-319-50520-6_2, ISSN: 0070-217X. 

Gobert AP, Sagrestani G, Delmas E, Wilson KT, Verriere TG, Dapoigny M, Del'homme C, Bernalier-Donadille A. The human intestinal microbiota of constipated-predominant irritable bowel syndrome patients exhibits anti-inflammatory propertiesSci Rep. 2016 Dec 12/16/2016; 6: 39399. PMID: 27982124, PII: srep39399, DOI: 10.1038/srep39399, ISSN: 2045-2322. 

Parang B, Bradley AM, Mittal MK, Short SP, Thompson JJ, Barrett CW, Naik RD, Bilotta AJ, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Hiebert SW, Williams CS. Myeloid translocation genes differentially regulate colorectal cancer programsOncogene [print-electronic]. 2016 Dec 12/8/2016; 35(49): 6341-9. PMID: 27270437, PMCID: PMC5140770, PII: onc2016167, DOI: 10.1038/onc.2016.167, ISSN: 1476-5594. 

Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM. TLR9 Activation Suppresses Inflammation in Response to Helicobacter pylori InfectionAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2016 Oct 10/6/2016; ajpgi.00175.2016. PMID: 27758771, PII: ajpgi.00175.2016, DOI: 10.1152/ajpgi.00175.2016, ISSN: 1522-1547. 

Singh K, Al-Greene NT, Verriere TG, Coburn LA, Asim M, Barry DP, Allaman MM, Hardbower DM, Delgado AG, Piazuelo MB, Vallance BA, Gobert AP, Wilson KTThe L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing BacteriaPLoS Pathog. 2016 Oct; 12(10): e1005984. PMID: 27783672, PII: PPATHOGENS-D-16-01126, DOI: 10.1371/journal.ppat.1005984, ISSN: 1553-7374. 

Hardbower DM, Asim M, Murray-Stewart T, Casero RA, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KTArginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infectionAmino Acids [print-electronic]. 2016 Oct; 48(10): 2375-88. PMID: 27074721, PMCID: PMC5042810, PII: 10.1007/s00726-016-2231-2, DOI: 10.1007/s00726-016-2231-2, ISSN: 1438-2199. 

Gobert AP, Wilson KTPolyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguiseFree Radic. Biol. Med [print-electronic]. 2016 Sep 9/25/2016; PMID: 27682363, PII: S0891-5849(16)30435-X, DOI: 10.1016/j.freeradbiomed.2016.09.024, ISSN: 1873-4596. 

Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagómez D, Barry DP, Allaman MM, Washington MK, Peek RM, Piazuelo MB, Wilson KTEGFR regulates macrophage activation and function in bacterial infectionJ. Clin. Invest [print-electronic]. 2016 Sep 9/1/2016; 126(9): 3296-312. PMID: 27482886, PMCID: PMC5004944, PII: 83585, DOI: 10.1172/JCI83585, ISSN: 1558-8238. 

Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG. Epigenetic and genetic variation in GATA5 is associated with gastric disease riskHum. Genet [print-electronic]. 2016 Aug; 135(8): 895-906. PMID: 27225266, PMCID: PMC4947561, PII: 10.1007/s00439-016-1687-1, DOI: 10.1007/s00439-016-1687-1, ISSN: 1432-1203. 

Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KTL-Arginine Availability and Metabolism Is Altered in Ulcerative ColitisInflamm. Bowel Dis. 2016 Aug; 22(8): 1847-58. PMID: 27104830, PMCID: PMC4956554, DOI: 10.1097/MIB.0000000000000790, ISSN: 1536-4844. 

Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion systemOncogene [print-electronic]. 2016 May 5/9/2016; PMID: 27157617, PII: onc2016158, DOI: 10.1038/onc.2016.158, ISSN: 1476-5594. 

Gobert AP, Wilson KTThe Immune Battle against Helicobacter pylori Infection: NO OffenseTrends Microbiol [print-electronic]. 2016 May; 24(5): 366-76. PMID: 26916789, PMCID: PMC4841705, PII: S0966-842X(16)00041-X, DOI: 10.1016/j.tim.2016.02.005, ISSN: 1878-4380. 

Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA. Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancerOncogene [print-electronic]. 2016 Apr 4/4/2016; PMID: 27041578, PII: onc201691, DOI: 10.1038/onc.2016.91, ISSN: 1476-5594. 

Gobert AP, Wilson KTThe Immune Battle against Helicobacter pylori Infection: NO OffenseTrends Microbiol [print-electronic]. 2016 Feb 2/22/2016; PMID: 26916789, PII: S0966-842X(16)00041-X, DOI: 10.1016/j.tim.2016.02.005, ISSN: 1878-4380. 

Garay J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, Zabaleta J. The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in miceCancer Lett [print-electronic]. 2016 Feb 2/1/2016; 371(1): 90-8. PMID: 26639196, PII: S0304-3835(15)00705-3, DOI: 10.1016/j.canlet.2015.10.037, ISSN: 1872-7980. 

Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in ColombiaSci Rep. 2016; 6: 18594. PMID: 26729566, PMCID: PMC4700446, PII: srep18594, DOI: 10.1038/srep18594, ISSN: 2045-2322. 

Wiese DM, Horst SN, Brown CT, Allaman MM, Hodges ME, Slaughter JC, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative ColitisPLoS ONE. 2016; 11(5): e0156387. PMID: 27227540, PMCID: PMC4882051, PII: PONE-D-15-55618, DOI: 10.1371/journal.pone.0156387, ISSN: 1932-6203. 

Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, Fei L, Washington MK, Minar P, Coburn LA, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial FunctionInflamm. Bowel Dis. 2015 Dec; 21(12): 2737-46. PMID: 26313694, PMCID: PMC4654638, DOI: 10.1097/MIB.0000000000000532, ISSN: 1536-4844. 

Gogoi M, Datey A, Wilson KT, Chakravortty D. Dual role of arginine metabolism in establishing pathogenesisCurr. Opin. Microbiol [print-electronic]. 2015 Nov 11/20/2015; 29: 43-8. PMID: 26610300, PII: S1369-5274(15)00153-8, DOI: 10.1016/j.mib.2015.10.005, ISSN: 1879-0364. 

Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. DNA Methylation Predicts Progression of Human Gastric LesionsCancer Epidemiol. Biomarkers Prev [print-electronic]. 2015 Oct; 24(10): 1607-13. PMID: 26269563, PMCID: PMC4592454, PII: 1055-9965.EPI-15-0388, DOI: 10.1158/1055-9965.EPI-15-0388, ISSN: 1538-7755. 

Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR. Hepatic TLR4 signaling in obese NAFLDAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Aug 8/15/2015; 309(4): G270-8. PMID: 26113297, PMCID: PMC4537925, PII: ajpgi.00304.2014, DOI: 10.1152/ajpgi.00304.2014, ISSN: 1522-1547. 

Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damageJ. Clin. Invest [print-electronic]. 2015 Jul 7/1/2015; 125(7): 2646-60. PMID: 26053663, PMCID: PMC4563672, PII: 76099, DOI: 10.1172/JCI76099, ISSN: 1558-8238. 

Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KTIncreased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidaseOncogene [print-electronic]. 2015 Jun; 34(26): 3429-40. PMID: 25174398, PMCID: PMC4345146, PII: onc2014273, DOI: 10.1038/onc.2014.273, ISSN: 1476-5594. 

Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cellsGut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288. 

Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarizationOncogene [print-electronic]. 2015 Apr 4/2/2015; 34(14): 1865-71. PMID: 24837365, PMCID: PMC4237684, PII: onc2014135, DOI: 10.1038/onc.2014.135, ISSN: 1476-5594. 

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injuryAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Mar 3/15/2015; 308(6): G562-71. PMID: 25573176, PMCID: PMC4360050, PII: ajpgi.00253.2014, DOI: 10.1152/ajpgi.00253.2014, ISSN: 1522-1547. 

Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287. 

Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitisMucosal Immunol [print-electronic]. 2014 Nov; 7(6): 1340-53. PMID: 24670427, PMCID: PMC4221190, PII: mi201421, DOI: 10.1038/mi.2014.21, ISSN: 1935-3456. 

Van Kaer L, Algood HM, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D. CD8aa¿ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunityImmunity [print-electronic]. 2014 Sep 9/18/2014; 41(3): 451-64. PMID: 25220211, PMCID: PMC4169715, PII: S1074-7613(14)00304-5, DOI: 10.1016/j.immuni.2014.08.010, ISSN: 1097-4180. 

Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KTHeme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pyloriJ. Immunol [print-electronic]. 2014 Sep 9/15/2014; 193(6): 3013-22. PMID: 25108023, PMCID: PMC4171064, PII: jimmunol.1401075, DOI: 10.4049/jimmunol.1401075, ISSN: 1550-6606. 

Hardbower DM, Peek RM, Wilson KTAt the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancerJ. Leukoc. Biol [print-electronic]. 2014 Aug; 96(2): 201-12. PMID: 24868089, PMCID: PMC4101087, PII: jlb.4BT0214-099R, DOI: 10.1189/jlb.4BT0214-099R, ISSN: 1938-3673. 

Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KTActivation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damageGastroenterology [print-electronic]. 2014 Jun; 146(7): 1739-51.e14. PMID: 24530706, PMCID: PMC4035375, PII: S0016-5085(14)00192-9, DOI: 10.1053/j.gastro.2014.02.005, ISSN: 1528-0012. 

Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN. Peroxisome proliferator-activated receptor d promotes colonic inflammation and tumor growthProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 May 5/13/2014; 111(19): 7084-9. PMID: 24763687, PMCID: PMC4024916, PII: 1324233111, DOI: 10.1073/pnas.1324233111, ISSN: 1091-6490. 

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interactionLab. Invest [print-electronic]. 2014 Apr; 94(4): 409-21. PMID: 24535260, PMCID: PMC3992484, PII: labinvest201410, DOI: 10.1038/labinvest.2014.10, ISSN: 1530-0307. 

Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA, Wilson KTSpermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermineAmino Acids [print-electronic]. 2014 Mar; 46(3): 531-42. PMID: 23820617, PMCID: PMC3812355, DOI: 10.1007/s00726-013-1531-z, ISSN: 1438-2199. 

Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitisJ. Immunol [print-electronic]. 2014 Feb 2/1/2014; 192(3): 1013-23. PMID: 24391216, PMCID: PMC4006992, PII: jimmunol.1300133, DOI: 10.4049/jimmunol.1300133, ISSN: 1550-6606. 

Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ. Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBDJ. Pediatr. Gastroenterol. Nutr. 2014 Feb; 58(2): 213-9. PMID: 24048170, PMCID: PMC3946904, DOI: 10.1097/MPG.0b013e3182a98df2, ISSN: 1536-4801. 

Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P. Human and Helicobacter pylori coevolution shapes the risk of gastric diseaseProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/28/2014; 111(4): 1455-60. PMID: 24474772, PMCID: PMC3910595, PII: 1318093111, DOI: 10.1073/pnas.1318093111, ISSN: 1091-6490. 

Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infectionMBio. 2014; 5(4): e01243-14. PMID: 25053783, PMCID: PMC4120195, PII: mBio.01243-14, DOI: 10.1128/mBio.01243-14, ISSN: 2150-7511. 

Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Dec; 305(11): G786-96. PMID: 24136787, PMCID: PMC3882435, PII: ajpgi.00279.2013, DOI: 10.1152/ajpgi.00279.2013, ISSN: 1522-1547. 

Hardbower DM, de Sablet T, Chaturvedi R, Wilson KTChronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer?Gut Microbes [print-electronic]. 2013 Nov; 4(6): 475-81. PMID: 23811829, PMCID: PMC3928159, PII: 25583, DOI: 10.4161/gmic.25583, ISSN: 1949-0984. 

Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosaeEpigenetics [print-electronic]. 2013 Nov; 8(11): 1153-61. PMID: 24128875, PMCID: PMC3927747, PII: 26072, DOI: 10.4161/epi.26072, ISSN: 1559-2308. 

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitisGut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288. 

Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KTDeletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell responseAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Aug 8/1/2013; 305(3): G225-40. PMID: 23703655, PMCID: PMC3742860, PII: ajpgi.00091.2013, DOI: 10.1152/ajpgi.00091.2013, ISSN: 1522-1547. 

Sierra JC, Hobbs S, Chaturvedi R, Yan F, Wilson KT, Peek RM, Polk DB. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cellsAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Jul 7/15/2013; 305(2): G196-203. PMID: 23681474, PMCID: PMC3725681, PII: ajpgi.00495.2012, DOI: 10.1152/ajpgi.00495.2012, ISSN: 1522-1547. 

Sheh A, Chaturvedi R, Merrell DS, Correa P, Wilson KT, Fox JG. Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cellsInfect. Immun [print-electronic]. 2013 Jul; 81(7): 2468-77. PMID: 23630959, PMCID: PMC3697613, PII: IAI.01182-12, DOI: 10.1128/IAI.01182-12, ISSN: 1098-5522. 

Parekh VV, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cellsJ. Immunol [print-electronic]. 2013 Mar 3/1/2013; 190(5): 1948-60. PMID: 23345328, PMCID: PMC3577977, PII: jimmunol.1201718, DOI: 10.4049/jimmunol.1201718, ISSN: 1550-6606. 

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KTSTAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokinesJ. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606. 

Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinomaCancer Res [print-electronic]. 2013 Feb 2/1/2013; 73(3): 1245-55. PMID: 23221387, PMCID: PMC3563732, PII: 0008-5472.CAN-12-3150, DOI: 10.1158/0008-5472.CAN-12-3150, ISSN: 1538-7445. 

Peek RM, Bimczok D, Wilson KT. Helicobacter pylori infection. In: Principles of Mucosal Immunology. Smith PD, MacDonald TT, Blumberg RS. Garland Science: New York. 2013. 

Gobert AP, Verriere T, de Sablet T, Peek RM, Chaturvedi R, Wilson KTHaem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cellsCell. Microbiol [print-electronic]. 2013 Jan; 15(1): 145-56. PMID: 23051580, PMCID: PMC3524338, DOI: 10.1111/cmi.12039, ISSN: 1462-5822. 

Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM. Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivoPLoS ONE [print-electronic]. 2013; 8(1): e54344. PMID: 23372710, PMCID: PMC3553174, PII: PONE-D-12-20127, DOI: 10.1371/journal.pone.0054344, ISSN: 1932-6203. 

Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humansJ. Clin. Invest [print-electronic]. 2013 Jan; 123(1): 479-92. PMID: 23257361, PMCID: PMC3533289, PII: 64373, DOI: 10.1172/JCI64373, ISSN: 1558-8238. 

Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesisPLoS ONE [electronic-print]. 2013; 8(7): e67845. PMID: 23861820, PMCID: PMC3701622, PII: PONE-D-13-14817, DOI: 10.1371/journal.pone.0067845, ISSN: 1932-6203. 

Sheh A, Piazuelo MB, Wilson KT, Correa P, Fox JG. Draft Genome Sequences of Helicobacter pylori Strains Isolated from Regions of Low and High Gastric Cancer Risk in ColombiaGenome Announc. 2013; 1(5): PMID: 24051318, PMCID: PMC3778201, PII: 1/5/e00736-13, DOI: 10.1128/genomeA.00736-13, ISSN: 2169-8287. 

Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KTHigh-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitisPLoS ONE. 2013; 8(12): e82300. PMID: 24367513, PMCID: PMC3867379, PII: PONE-D-13-38373, DOI: 10.1371/journal.pone.0082300, ISSN: 1932-6203. 

Loh JT, Friedman DB, Piazuelo MB, Bravo LE, Wilson KT, Peek RM, Correa P, Cover TL. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expressionInfect. Immun [print-electronic]. 2012 Sep; 80(9): 3094-106. PMID: 22710874, PMCID: PMC3418733, PII: IAI.00232-12, DOI: 10.1128/IAI.00232-12, ISSN: 1098-5522. 

Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cellsGut [print-electronic]. 2012 Sep; 61(9): 1250-60. PMID: 22157330, PMCID: PMC3419307, PII: gutjnl-2011-301078, DOI: 10.1136/gutjnl-2011-301078, ISSN: 1468-3288. 

Singh K, Coburn LA, Barry DP, Boucher JL, Chaturvedi R, Wilson KTL-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitutionAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 May 5/1/2012; 302(9): G1061-73. PMID: 22361732, PMCID: PMC3362080, PII: ajpgi.00544.2011, DOI: 10.1152/ajpgi.00544.2011, ISSN: 1522-1547. 

Gobert AP, Wilson KTEditorial: Orchestration of macrophage polarization by polyamines [editorial]J. Leukoc. Biol. 2012 May; 91(5): 677-9. PMID: 22547131, PMCID: PMC3336771, PII: 91/5/677, DOI: 10.1189/jlb.0112047, ISSN: 1938-3673. 

Sicinschi LA, Correa P, Bravo LE, Peek RM, Wilson KT, Loh JT, Yepez MC, Gold BD, Thompson DT, Cover TL, Schneider BG. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic childrenHelicobacter. 2012 Apr; 17(2): 96-106. PMID: 22404439, PMCID: PMC3305281, DOI: 10.1111/j.1523-5378.2011.00919.x, ISSN: 1523-5378. 

Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated miceAm. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): G504-14. PMID: 22173918, PMCID: PMC3311435, PII: ajpgi.00312.2011, DOI: 10.1152/ajpgi.00312.2011, ISSN: 1522-1547. 

Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KTArginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesisAmino Acids [print-electronic]. 2012 Feb; 42(2-3): 627-40. PMID: 21874531, PMCID: PMC3258477, DOI: 10.1007/s00726-011-1038-4, ISSN: 1438-2199. 

Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KTL-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitisPLoS ONE [print-electronic]. 2012; 7(3): e33546. PMID: 22428068, PMCID: PMC3299802, PII: PONE-D-12-00729, DOI: 10.1371/journal.pone.0033546, ISSN: 1932-6203.

Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk DB, Yan F. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factorPLoS ONE [print-electronic]. 2012; 7(5): e36418. PMID: 22574158, PMCID: PMC3344856, PII: PONE-D-11-19780, DOI: 10.1371/journal.pone.0036418, ISSN: 1932-6203. 

Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promotersPLoS ONE [print-electronic]. 2012; 7(12): e51205. PMID: 23251453, PMCID: PMC3521008, PII: PONE-D-12-22965, DOI: 10.1371/journal.pone.0051205, ISSN: 1932-6203. 

Chaturvedi R, de Sablet T, Peek RM, Wilson KTSpermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer riskGut Microbes. 2012 Jan; 3(1): 48-56. PMID: 22555547, PMCID: PMC3337125, PII: 19345, DOI: 10.4161/gmic.19345, ISSN: 1949-0984. 

Gobert AP, Asim M, Piazuelo MB, Verriere T, Scull BP, de Sablet T, Glumac A, Lewis ND, Correa P, Peek RM, Chaturvedi R, Wilson KTDisruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1J. Immunol [print-electronic]. 2011 Nov 11/15/2011; 187(10): 5370-9. PMID: 21987660, PMCID: PMC3208050, PII: jimmunol.1102111, DOI: 10.4049/jimmunol.1102111, ISSN: 1550-6606. 

Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KTSpermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagAGastroenterology [print-electronic]. 2011 Nov; 141(5): 1696-708.e1. PMID: 21839041, PMCID: PMC3202654, PII: S0016-5085(11)01080-8, DOI: 10.1053/j.gastro.2011.07.045, ISSN: 1528-0012. 

Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB. STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunctionInflamm. Bowel Dis [print-electronic]. 2011 Nov; 17(11): 2224-34. PMID: 21308881, PMCID: PMC3120916, DOI: 10.1002/ibd.21628, ISSN: 1536-4844. 

Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigenJ. Immunol [print-electronic]. 2011 Oct 10/15/2011; 187(8): 4051-60. PMID: 21900182, PMCID: PMC3186831, PII: jimmunol.1101052, DOI: 10.4049/jimmunol.1101052, ISSN: 1550-6606. 

de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KTPhylogeographic origin of Helicobacter pylori is a determinant of gastric cancer riskGut [print-electronic]. 2011 Sep; 60(9): 1189-95. PMID: 21357593, PMCID: PMC3133872, PII: gut.2010.234468, DOI: 10.1136/gut.2010.234468, ISSN: 1468-3288. 

Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activationOncogene [print-electronic]. 2011 Jul 7/21/2011; 30(29): 3234-47. PMID: 21383692, PMCID: PMC3591522, PII: onc201143, DOI: 10.1038/onc.2011.43, ISSN: 1476-5594. 

Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanismJ. Clin. Invest [print-electronic]. 2011 Jun; 121(6): 2242-53. PMID: 21606592, PMCID: PMC3104743, PII: 44031, DOI: 10.1172/JCI44031, ISSN: 1558-8238. 

Lewis ND, Asim M, Barry DP, de Sablet T, Singh K, Piazuelo MB, Gobert AP, Chaturvedi R, Wilson KTImmune evasion by Helicobacter pylori is mediated by induction of macrophage arginase IIJ. Immunol [print-electronic]. 2011 Mar 3/15/2011; 186(6): 3632-41. PMID: 21296975, PMCID: PMC3069806, PII: jimmunol.1003431, DOI: 10.4049/jimmunol.1003431, ISSN: 1550-6606. 

Rana T, Misra S, Mittal MK, Farrow AL, Wilson KT, Linton MF, Fazio S, Willis IM, Chaudhuri G. Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by LeishmaniaJ. Biol. Chem [print-electronic]. 2011 Feb 2/25/2011; 286(8): 6614-26. PMID: 21149457, PMCID: PMC3057815, PII: M110.181735, DOI: 10.1074/jbc.M110.181735, ISSN: 1083-351X. 

Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma modelCancer Res [print-electronic]. 2011 Feb 2/15/2011; 71(4): 1302-12. PMID: 21303973, PMCID: PMC3150168, PII: 0008-5472.CAN-10-3317, DOI: 10.1158/0008-5472.CAN-10-3317, ISSN: 1538-7445. 

Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KTThe apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitisJ. Biol. Chem [print-electronic]. 2011 Feb 2/4/2011; 286(5): 3839-50. PMID: 21115487, PMCID: PMC3030385, PII: M110.176719, DOI: 10.1074/jbc.M110.176719, ISSN: 1083-351X. 

Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ productionGastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012. 

Barry DP, Asim M, Leiman DA, de Sablet T, Singh K, Casero RA, Chaturvedi R, Wilson KTDifluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 inductionPLoS ONE. 2011; 6(2): e17510. PMID: 21386987, PMCID: PMC3046249, DOI: 10.1371/journal.pone.0017510, ISSN: 1932-6203. 

Gobert AP, Chaturvedi R, Wilson KTMethods to evaluate alterations in polyamine metabolism caused by Helicobacter pylori infectionMethods Mol. Biol. 2011; 720: 409-25. PMID: 21318889, PMCID: PMC3069756, DOI: 10.1007/978-1-61779-034-8_26, ISSN: 1940-6029. 

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KTCationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infectionPLoS ONE [print-electronic]. 2011; 6(12): e29046. PMID: 22194986, PMCID: PMC3237590, PII: PONE-D-11-18825, DOI: 10.1371/journal.pone.0029046, ISSN: 1932-6203. 

Schneider BG, Peng DF, Camargo MC, Piazuelo MB, Sicinschi LA, Mera R, Romero-Gallo J, Delgado AG, Bravo LE, Wilson KT, Peek RM, Correa P, El-Rifai W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancerInt. J. Cancer. 2010 Dec 12/1/2010; 127(11): 2588-97. PMID: 20178103, PMCID: PMC2916942, DOI: 10.1002/ijc.25274, ISSN: 1097-0215. 

Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA, Gobert AP, Wilson KTPolyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide ProductionGastroenterology [print-electronic]. 2010 Nov; 139(5): 1686-98, 1698.e1. PMID: 20600019, PMCID: PMC2967614, PII: S0016-5085(10)01003-6, DOI: 10.1053/j.gastro.2010.06.060, ISSN: 1528-0012. 

Wroblewski LE, Peek RM, Wilson KTHelicobacter pylori and gastric cancer: factors that modulate disease riskClin. Microbiol. Rev. 2010 Oct; 23(4): 713-39. PMID: 20930071, PMCID: PMC2952980, PII: 23/4/713, DOI: 10.1128/CMR.00011-10, ISSN: 1098-6618. 

Hong SK, Chaturvedi R, Piazuelo MB, Coburn LA, Williams CS, Delgado AG, Casero RA, Schwartz DA, Wilson KTIncreased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activityInflamm. Bowel Dis. 2010 Sep; 16(9): 1557-66. PMID: 20127992, PMCID: PMC2894261, DOI: 10.1002/ibd.21224, ISSN: 1536-4844. 

Peek RM, Fiske C, Wilson KTRole of innate immunity in Helicobacter pylori-induced gastric malignancyPhysiol. Rev. 2010 Jul; 90(3): 831-58. PMID: 20664074, PMCID: PMC2990353, PII: 90/3/831, DOI: 10.1152/physrev.00039.2009, ISSN: 1522-1210. 

Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KTHelicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophagesJ. Biol. Chem [print-electronic]. 2010 Jun 6/25/2010; 285(26): 20343-57. PMID: 20410304, PMCID: PMC2888446, PII: M110.116988, DOI: 10.1074/jbc.M110.116988, ISSN: 1083-351X. 

Lewis ND, Asim M, Barry DP, Singh K, de Sablet T, Boucher JL, Gobert AP, Chaturvedi R, Wilson KTArginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophagesJ. Immunol [print-electronic]. 2010 Mar 3/1/2010; 184(5): 2572-82. PMID: 20097867, PMCID: PMC2841360, PII: jimmunol.0902436, DOI: 10.4049/jimmunol.0902436, ISSN: 1550-6606. 

Correa P, Piazuelo MB, Wilson KTPathology of gastric intestinal metaplasia: clinical implicationsAm. J. Gastroenterol. 2010 Mar; 105(3): 493-8. PMID: 20203636, PMCID: PMC2895407, PII: ajg2009728, DOI: 10.1038/ajg.2009.728, ISSN: 1572-0241. 

Correa P, Piazuelo MB, Wilson KTPathology of gastric intestinal metaplasia: clinical implicationsAm. J. Gastroenterol. 2010 Mar; 105(3): 493-8. PMID: 20203636, PMCID: PMC2895407, PII: ajg2009728, DOI: 10.1038/ajg.2009.728, ISSN: 1572-0241. 

Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected miceCancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445. 

Hong SK, Maltz BE, Coburn LA, Slaughter JC, Chaturvedi R, Schwartz DA, Wilson KTIncreased serum levels of L-arginine in ulcerative colitis and correlation with disease severityInflamm. Bowel Dis. 2010 Jan; 16(1): 105-11. PMID: 19637336, PMCID: PMC2795785, DOI: 10.1002/ibd.21035, ISSN: 1536-4844. 

Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosisGastroenterology [print-electronic]. 2009 Apr; 136(4): 1297-1307, e1. PMID: 19250983, PMCID: PMC2878739, PII: S0016-5085(08)02317-2, DOI: 10.1053/j.gastro.2008.12.059, ISSN: 1528-0012. 

O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factorJ. Biol. Chem [print-electronic]. 2008 Aug 8/29/2008; 283(35): 23922-30. PMID: 18579524, PMCID: PMC2527108, PII: M801144200, DOI: 10.1074/jbc.M801144200, ISSN: 0021-9258. 

Singh K, Chaturvedi R, Asim M, Barry DP, Lewis ND, Vitek MP, Wilson KTThe apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activationJ. Biol. Chem [print-electronic]. 2008 Jun 6/13/2008; 283(24): 16752-61. PMID: 18417477, PMCID: PMC2423260, PII: M710530200, DOI: 10.1074/jbc.M710530200, ISSN: 0021-9258. 

Algood HM, Gallo-Romero J, Wilson KT, Peek RM, Cover TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune responseFEMS Immunol. Med. Microbiol [print-electronic]. 2007 Dec; 51(3): 577-86. PMID: 17919297, PII: FIM338, DOI: 10.1111/j.1574-695X.2007.00338.x, ISSN: 0928-8244. 

Chaturvedi R, Asim M, Lewis ND, Algood HM, Cover TL, Kim PY, Wilson KTL-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pyloriInfect. Immun [print-electronic]. 2007 Sep; 75(9): 4305-15. PMID: 17562760, PMCID: PMC1951193, PII: IAI.00578-07, DOI: 10.1128/IAI.00578-07, ISSN: 0019-9567. 

Wilson KT, Crabtree JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studiesGastroenterology. 2007 Jul; 133(1): 288-308. PMID: 17631150, PII: S0016-5085(07)00990-0, DOI: 10.1053/j.gastro.2007.05.008, ISSN: 0016-5085. 

Bussiere FI, Chaturvedi R, Asim M, Hoek KL, Cheng Y, Gainor J, Scholz A, Khan WN, Wilson KTLow multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytesCancer Res. 2006 Jul 7/1/2006; 66(13): 6834-42. PMID: 16818661, PII: 66/13/6834, DOI: 10.1158/0008-5472.CAN-05-4197, ISSN: 0008-5472. 

Chaturvedi, R, Wilson, KT. In Wang, JY, Casero, RA, Jr., eds., Polyamine Cell Signalling: Physiology, Pharmacology, and Cancer Research. Totowa, NJ: Human Press. [place unknown: publisher unknown]; 2006. 

Cross RK, Wilson KT, Binion DG. Narcotic use in patients with Crohn's diseaseAm. J. Gastroenterol. 2005 Oct; 100(10): 2225-9. PMID: 16181373, PII: AJG256, DOI: 10.1111/j.1572-0241.2005.00256.x, ISSN: 0002-9270. 

Cheng Y, Chaturvedi R, Asim M, Bussière FI, Scholz A, Xu H, Casero RA, Wilson KTHelicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-MycJ. Biol. Chem [print-electronic]. 2005 Jun 6/10/2005; 280(23): 22492-6. PMID: 15843384, PII: C500122200, DOI: 10.1074/jbc.C500122200, ISSN: 0021-9258. 

Cross RK, Wilson KT, Binion DG. Polypharmacy and Crohn's diseaseAliment. Pharmacol. Ther. 2005 May 5/15/2005; 21(10): 1211-6. PMID: 15882241, PII: APT2429, DOI: 10.1111/j.1365-2036.2005.02429.x, ISSN: 0269-2813. 

Gobert AP, Wilson KT, Martin C. Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune systemArch. Immunol. Ther. Exp. (Warsz.). 2005 May; 53(3): 234-44. PMID: 15995584, PII: 7450, ISSN: 0004-069X. 

Bussière FI, Chaturvedi R, Cheng Y, Gobert AP, Asim M, Blumberg DR, Xu H, Kim PY, Hacker A, Casero RA, Wilson KTSpermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translationJ. Biol. Chem [print-electronic]. 2005 Jan 1/28/2005; 280(4): 2409-12. PMID: 15548540, PII: C400498200, DOI: 10.1074/jbc.C400498200, ISSN: 0021-9258. 

Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA, Wilson KTSpermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesisCancer Res. 2004 Dec 12/1/2004; 64(23): 8521-5. PMID: 15574757, PII: 64/23/8521, DOI: 10.1158/0008-5472.CAN-04-3511, ISSN: 0008-5472. 

Chaturvedi R, Cheng Y, Asim M, Bussière FI, Xu H, Gobert AP, Hacker A, Casero RA, Wilson KTInduction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarizationJ. Biol. Chem [print-electronic]. 2004 Sep 9/17/2004; 279(38): 40161-73. PMID: 15247269, PII: M401370200, DOI: 10.1074/jbc.M401370200, ISSN: 0021-9258. 

Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA, Wilson KTProtective role of arginase in a mouse model of colitisJ. Immunol. 2004 Aug 8/1/2004; 173(3): 2109-17. PMID: 15265947, PII: 173/3/2109, ISSN: 0022-1767. 

Duleu S, Vincendeau P, Courtois P, Semballa S, Lagroye I, Daulouède S, Boucher JL, Wilson KT, Veyret B, Gobert AP. Mouse strain susceptibility to trypanosome infection: an arginase-dependent effectJ. Immunol. 2004 May 5/15/2004; 172(10): 6298-303. PMID: 15128819, ISSN: 0022-1767. 

Ma X, Yang Q, Wilson KT, Kundu N, Meltzer SJ, Fulton AM. Promoter methylation regulates cyclooxygenase expression in breast cancerBreast Cancer Res [print-electronic]. 2004; 6(4): R316-21. PMID: 15217498, PMCID: PMC468630, PII: bcr793, DOI: 10.1186/bcr793, ISSN: 1465-542X. 

Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KTCutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pyloriJ. Immunol. 2003 Oct 10/15/2003; 171(8): 3913-7. PMID: 14530307, ISSN: 0022-1767. 

Cross RK, Wilson KTNitric oxide in inflammatory bowel diseaseInflamm. Bowel Dis. 2003 May; 9(3): 179-89. PMID: 12792224, ISSN: 1078-0998. 

Panchal PC, Forman JS, Blumberg DR, Wilson KTHelicobacter pylori infection: pathogenesisCurr. Opin. Gastroenterol. 2003 Jan; 19(1): 4-10. PMID: 15699887, PII: 00001574-200301000-00002, ISSN: 0267-1379. 

Rafiee P, Johnson CP, Li MS, Ogawa H, Heidemann J, Fisher PJ, Lamirand TH, Otterson MF, Wilson KT, Binion DG. Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endotheliumJ. Biol. Chem [print-electronic]. 2002 Sep 9/20/2002; 277(38): 35605-15. PMID: 12110686, PII: M205826200, DOI: 10.1074/jbc.M205826200, ISSN: 0021-9258. 

Gobert AP, Mersey BD, Cheng Y, Blumberg DR, Newton JC, Wilson KTCutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthaseJ. Immunol. 2002 Jun 6/15/2002; 168(12): 6002-6. PMID: 12055207, ISSN: 0022-1767. 

Gobert AP, Cheng Y, Wang JY, Boucher JL, Iyer RK, Cederbaum SD, Casero RA, Newton JC, Wilson KTHelicobacter pylori induces macrophage apoptosis by activation of arginase IIJ. Immunol. 2002 May 5/1/2002; 168(9): 4692-700. PMID: 11971019, ISSN: 0022-1767. 

Wilson KTAngiogenic markers, neovascularization and malignant deformation of Barrett's esophagusDis. Esophagus. 2002; 15(1): 16-21. PMID: 12060038, PII: 212, ISSN: 1120-8694. 

Gobert AP, McGee DJ, Akhtar M, Mendz GL, Newton JC, Cheng Y, Mobley HL, Wilson KTHelicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survivalProc. Natl. Acad. Sci. U.S.A. 2001 Nov 11/20/2001; 98(24): 13844-9. PMID: 11717441, PMCID: PMC61129, PII: 98/24/13844, DOI: 10.1073/pnas.241443798, ISSN: 0027-8424. 

Akhtar M, Cheng Y, Magno RM, Ashktorab H, Smoot DT, Meltzer SJ, Wilson KTPromoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cellsCancer Res. 2001 Mar 3/15/2001; 61(6): 2399-403. PMID: 11289104, ISSN: 0008-5472. 

Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Nishizuka S, James SP, Wilson KT, Herman JG, Meltzer SJ. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasiaOncogene. 2001 Jan 1/18/2001; 20(3): 329-35. PMID: 11313962, DOI: 10.1038/sj.onc.1204104, ISSN: 0950-9232. 

Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KTDeficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesionFree Radic. Biol. Med. 2000 Nov 11/1/2000; 29(9): 881-8. PMID: 11063913, PII: S0891-5849(00)00391-9, ISSN: 0891-5849. 

Meyer F, Wilson KT, James SP. Modulation of innate cytokine responses by products of Helicobacter pyloriInfect. Immun. 2000 Nov; 68(11): 6265-72. PMID: 11035734, PMCID: PMC97708, ISSN: 0019-9567. 

Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1Cancer Res. 2000 Sep 9/1/2000; 60(17): 4864-8. PMID: 10987299, ISSN: 0008-5472. 

Tsuchiya T, Tamura G, Sato K, Endoh Y, Sakata K, Jin Z, Motoyama T, Usuba O, Kimura W, Nishizuka S, Wilson KT, James SP, Yin J, Fleisher AS, Zou T, Silverberg SG, Kong D, Meltzer SJ. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epitheliaOncogene. 2000 Jul 7/27/2000; 19(32): 3642-6. PMID: 10951570, DOI: 10.1038/sj.onc.1203704, ISSN: 0950-9232. 

Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomasJ. Natl. Cancer Inst. 2000 Apr 4/5/2000; 92(7): 569-73. PMID: 10749913, ISSN: 0027-8874. 

Malamud A, Wilson KTTreatment of gastrointestinal infectionsCurr. Opin. Gastroenterol. 2000 Jan; 16(1): 51-5. PMID: 17024016, PII: 00001574-200001000-00009, ISSN: 0267-1379. 

Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, Meltzer SJ, Wilson KTIncreased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritisGastroenterology. 1999 Jun; 116(6): 1319-29. PMID: 10348815, PII: S0016508599005442, ISSN: 0016-5085. 

Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instabilityCancer Res. 1999 Mar 3/1/1999; 59(5): 1090-5. PMID: 10070967, ISSN: 0008-5472. 

Wilson KT, Fantry GT. Pathogenesis of Helicobacter pylori infectionCurr. Opin. Gastroenterol. 1999 Jan; 15(1): 66-71. PMID: 17023920, PII: 00001574-199901000-00012, ISSN: 0267-1379. 

Varanasi RV, Fantry GT, Wilson KTDecreased prevalence of Helicobacter pylori infection in gastroesophageal reflux diseaseHelicobacter. 1998 Sep; 3(3): 188-94. PMID: 9731990, ISSN: 1083-4389. 

Binion DG, Fu S, Ramanujam KS, Chai YC, Dweik RA, Drazba JA, Wade JG, Ziats NP, Erzurum SC, Wilson KTINOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesionAm. J. Physiol. 1998 Sep; 275(3 Pt 1): G592-603. PMID: 9724273, ISSN: 0002-9513. 

Wilson KT, Fu S, Ramanujam KS, Meltzer SJ. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomasCancer Res. 1998 Jul 7/15/1998; 58(14): 2929-34. PMID: 9679948, ISSN: 0008-5472. 

Kundu N, Dorsey R, Jackson MJ, Guiterrez P, Wilson K, Fu S, Ramanujam K, Thomas E, Fulton AM. Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxideInt. J. Cancer. 1998 May 5/29/1998; 76(5): 713-9. PMID: 9610731, PII: 10.1002/(SICI)1097-0215(19980529)76:5<713::AID-IJC17>3.0.CO;2-4, ISSN: 0020-7136. 

Wilson KT, Ramanujam KS, Mobley HL, Musselman RF, James SP, Meltzer SJ. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell lineGastroenterology. 1996 Dec; 111(6): 1524-33. PMID: 8942731, PII: S0016-5085(96)70014-8, ISSN: 0016-5085. 

Wilson KT, Vaandrager AB, De Vente J, Musch MW, De Jonge HR, Chang EB. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transportAm. J. Physiol. 1996 Mar; 270(3 Pt 1): C832-40. PMID: 8638664, ISSN: 0002-9513. 

Wilson, KT, Chang, EB. Immune regulation of intestinal secretion. Practical Gastroenterol. 1994; 3: 22J-22Q. 

Wilson KT, Xie Y, Musch MW, Chang EB. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colonJ. Pharmacol. Exp. Ther. 1993 Jul; 266(1): 224-30. PMID: 8331560, ISSN: 0022-3565. 

Wilson, KT, Musch, MW, Chang, EB. In MacDermott, R, Stenson, W, eds., Inflammatory Bowel Disease. New York: Elsevier. [place unknown: publisher unknown]; 1992.