Welcome to the Newcomb Lab...

Our laboratory uses multi-disciplinary approaches to determine how sex hormones regulate inflammatory mechanisms important in asthma. After puberty there is a large swing in prevalence with women being two-times more likely than men to have severe asthma.10 However, when women reach menopause the prevalence of asthma equalizes with regard to gender.12 This change in the prevalence of severe asthma strongly suggests a role for sex hormones in asthma pathogenesis.13 Since asthma is a chronic inflammatory disease, it is highly likely that sex differences in airway inflammation influence the asthma prevalence. To delineate these mechanisms, we isolate PBMCs from the blood of patients with asthma, determine in vitro cell signaling mechanisms involved with T cell differentiation and innate lymphoid cell stimulation, and use mouse models of airway inflammation. This multi-pronged approach allows us to determine mechanisms which regulate airway inflammation from many different angles, provides rapid generation of data and the foundational research required for the development of therapeutics and strategies for to treat asthma.