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Unleashing the immune system to fight cancer has been a major goal of medicine for over a century. Recently, a number of immune-based strategies have resulted in significant success. Particularly effective have been immune checkpoint inhibitors, at least for some cancer types. These treatments are now being used in many cancers globally. V-POINT (Vanderbilt Program for Optimizing ImmuNo-oncology Therapies) is a multi-disciplinary effort at Vanderbilt to more effectively and safely use immune therapy in cancer patients, using cutting-edge basic science, clinical research, and education.